As a preliminary step to beginning to assess the usefulness of clinical vignettes to measure ethical sensitivity in undergraduate medical students, five clinical vignettes with seven to nine ethical issues each were created. The ethical issues in the vignettes were discussed and outlined by an expert panel. One randomly selected vignette was presented to first, second and third year students at the University of Toronto as part of another examination. The students were asked to list the issues presented by the (...) patient problem. Responses from 281 students were obtained. These students identified an average of 2.72 ethical issues per vignette. Each response was classified under the domains of autonomy, beneficence and justice. Comparisons were made between classes and between vignettes. There was considerable variation between classes and the responses to different vignettes seem to indicate that different vignettes measure the various domains in different ways. It does appear that the use of vignettes is one way to measure aspects of ethical sensitivity in medical students but more study is required to clarify exactly what is being measured. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Cadherin‐mediated cell‐cell adhesion is perturbed in protein tyrosine kinase (PTK)‐transformed cells. While cadherins themselves appear to be poor PTK substrates, their cytoplasmic binding partners, the Arm catenins, are excellent PTK substrates and therefore good candidates for mediating PTK‐induced changes in cadherin behavior. These proteins, p120ctn, β‐catenin and plakoglobin, bind to the cytoplasmic region of classical cadherins and function to modulate adhesion and/or bridge cadherins to the actin cytoskeleton. In addition, as demonstrated recently for β‐catenin, these proteins also have crucial signaling (...) roles that may or may not be related to their effects on cell‐cell adhesion. Tyrosine phosphorylation of cadherin complexes is well documented and widely believed to modulate cell adhesiveness. The data to date, however, is largely correlative and the mechanism of action remains unresolved. In this review, we discuss the current literature and suggest models whereby tyrosine phosphorylation of Arm catenins contribute to regulation or perturbation of cadherin function. (shrink)

M. Tulli Ciceronis libri qui ad rem publicam et ad philosophiam spectant; vol. ix. Cato Maior de Senectute, Laelius de Amicitia; 50 Pf. vol. x. De Officiis; 80 Pf. ed. Th. Schiche, Leipzig, Freytag.M. Tulli Ciceronis Orationes Selectae; vol. i. Oratio pro Sex. Roscio Arnerino; 30 Pf. vol. ii. In Q. Caecilium Diuinatio, in C. Verrem Accusationis, Lib. iv. v.; ed. H. Nohl; 80 Pf. Leipzig, Freytag.M. Tulli Ciceronis Scripta quae remanserunt omnia. Recognovit C. F. W. Mueller. Partis ii. vol. (...) iii. Leipzig, Teubner, 1886. 2 Mk. 10. (shrink)

Proving academic plagiarism is difficult. This volume borrows principles from textual criticism to illustrate new techniques for demonstrating plagiarism. These techniques can be used to persuade others—colleagues, editors, publishers, and research integrity committees—when academic plagiarism has been committed.

Purpose: Constructivism postulates that the perceived reality is a complex construct formed during development. Depending on the particular school, these inner constructs take on different forms and structures and affect cognition in different ways. The purpose of this article is to address the questions of how and, even more importantly, why we form such inner constructs. Approach: This article proposes that brain development is controlled by an inherent anticipatory drive, which biases learning towards the formation of forward predictive structures and (...) inverse goal-oriented control structures. This drive, in combination with increasingly complex environmental interactions during cognitive development, enforces the structuring of our conscious self, which is embedded in a constructed inner reality. Essentially, the following questions are addressed: Which basic mechanisms lead us to the construction of inner realities? How are these emergent inner realities structured? How is the self represented within the inner realities? And consequently, which cognitive structures constitute the media for conscious thought and selfconsciousness? Findings: Due to the anticipatory drive, representations in the brain shape themselves predominantly purposefully or intentionally. Taking a developmental, evolutionary perspective, we show how the brain is forced to develop progressively complex and abstract representations of the self embedded in the constructed inner realities. These self representations can evoke different stages of self-consciousness. Implications: The anticipatory drive shapes brain structures and cognition during the development of progressively more complex, competent, and flexible goal-oriented bodyenvironment interactions. Self-consciousness develops because increasingly abstract, individualizing self representations are necessary to realize these progressively more challenging environmental interactions. (shrink)

This volume is the first book-length study on post-publication responses to academic plagiarism in humanities disciplines. It demonstrates that the correction of the scholarly literature for plagiarism is not a task for editors and publishers alone; each member of the research community has an indispensable role in maintaining the integrity of the published literature in the aftermath of plagiarism. If untreated, academic plagiarism damages the integrity of the scholarly record, corrupts the surrounding academic enterprise, and creates inefficiencies across all levels (...) of knowledge production. By providing case studies from the field of philosophy and related disciplines, the volume exhibits that current post-publication responses to academic plagiarism are insufficient. It catalogues how humanities disciplines fall short in comparison with the natural and biomedical sciences for ensuring the integrity of the body of published research. This volume provides clarity about how to conceptualize the scholarly record, surveys the traditional methods for correcting it, and argues for new interventions to improve the reliability of the body of published research. The book is valuable not only to those in the field of philosophy and other humanities disciplines, but also to those interested in research ethics, meta-science, and the sociology of research. (shrink)

Актуальність дослідження проблеми самореалізації особистості у спорті як головний мегатренд є специфічною особливістю глобалізації, в контексті якої малодослідженими є соціоантропологічні виміри, пов’язані з людиною. Ця проблема виникає тому, що починається переосмислюватися феномен людини як суб’єкта спортивної діяльності. При цьому спортивна парадигма в умовах глобалізації починає переосмислюватися, так як має свої плюси і мінуси. Мета дослідження – концептуалізація самореалізації особистості у спорті як головний мегатренд глобального суспільства в контексті соціоантропологічних вимірів. Завдання дослідження : вивчення проблем управління спортом, що детермінуються масштабними трансформаціями (...) сучасного соціуму; дослідження принципів, на основі яких відбувається формування спортивної парадигми в умовах глобалізації; аналіз реалізації можливостей саморозвитку людини у світі спорту в умовах глобалізації; формування нової спортивної парадигми, яка дозволяє виявити міру співвіднесеності тенденцій спорту і потреб у розвитку сутнісних сил людини як їх родової сутності. Аналіз останніх досліджень і публікацій, з яких започатковано розв’язання даної проблеми: використання статей авторів Vizitei N., Voronkova, V.., Edensor, T.., Hambrecht, H. U., Holowchak, M., Reid H., Mechikoff, R., Morgan, W. J., Olexenko, R., Scott, R., в яких вирішуються проблеми людини та її самореалізації у світі спорту та соціоантропологічні засади, які є малодослідженими у сфері спорту. Методологія дослідження - антропологічний та соціоаксіологічний методи, що сприяють проникненню в світ спортивної людини, еволюції спортивної парадигми в умовах глобалізації, позначеною багатьма проблемами людино вимірності, так як спорт пов'язаний і з комерціалізацією. Наукова новизна – у виявленні проблем глобалізації, що впливають на спортивну людину, спортивну діяльність та в цілому на світ спорту. Результати дослідження : самореалізація людини у спорті в умовах глобалізації, що представляє якісну характеристику спортивного світу, започатковану різноманітними спортивними практиками спортивного світу та розкриває рух до інтеграції та цілісності. Висновок - концепція самореалізації особистості у спорті як головний мегатренд формування спортивної парадигми в умовах глобалізації потребують її доповнення соціоантропологічними виміри. (shrink)

Qualitative fieldwork research on sensitive topics sometimes requires that interviewees be granted confidentiality and anonymity. When qualitative researchers later publish their findings, they must ensure that any statements obtained during fieldwork interviews cannot be traced back to the interviewees. Given these protections to interviewees, the integrity of the published findings cannot usually be verified or replicated by third parties, and the scholarly community must trust the word of qualitative researchers when they publish their results. This trust is fundamentally abused, however, (...) when researchers publish articles reporting qualitative fieldwork data that they never collected. Using only publicly available information, I argue that a 2017 article in an Elsevier foreign policy and international relations journal presents anonymised fieldwork interviews that could not have occurred as described. As an exercise in post-publication peer review (PPPR), this paper examines the evidence that calls into question the reliability of the putative fieldwork quotations. I show further that the 2017 article is not a unique case. The anonymity and confidentiality protections common in some areas of research create an ethical problem: the protections necessary for obtaining research data can be used as a cover to hide substandard research practices as well as research misconduct. (shrink)

Disguised plagiarism often goes undetected. An especially subtle type of disguised plagiarism is translation plagiarism, which occurs when the work of one author is republished in a different language with authorship credit taken by someone else. I focus on the challenge of demonstrating this subtle variety of plagiarism and examine the corruptive influence that plagiarizing articles exert on unsuspecting researchers who later cite them in the downstream literature as genuine products of research. I conclude by arguing that an open discussion (...) of plagiarizing articles in philosophy is necessary for maintaining the reliability of the body of published research and for restoring integrity to scholarly communication. (shrink)

In this article, we argue that scientists and technologists associated with the nuclear industry are building support for small modular reactors by advancing five rhetorical visions imbued with elements of fantasy that cater to various social expectations. The five visions are as follows: a vision of risk-free energy would eliminate catastrophic accidents and meltdowns. A vision of indigenous self-energization would see SMRs empowering remote communities and developing economies. A vision of water security would see SMR-powered desalination plants satisfying the world’s (...) water needs. A vision of environmental nirvana would see SMRs providing waste-free and carbon-free electricity to preserve the earth’s biosphere. A vision of space exploration would see SMRs assisting in the colonization of the moon, Mars, and possibly other worlds. These visions help create a symbolic convergence among promoters, serving to attract political and financial support, and erasing previous nuclear failures from public discourse. Moreover, underlying these visions is a technological utopian ideal world where SMRs would generate plentiful energy of multiple kinds, offering the necessary means for a life of comfort for all people by meeting various needs and without any environmental externalities or cause for concern about accidents. (shrink)

This article documents how a serial plagiarism case discovered over a decade ago continues to generate negative effects in the downstream research on medieval and early modern philosophy. The ongoing positive citation of the 40 plagiarizing articles and book chapters – including those retracted by their publishers – affects the reliability of later scholarship in several ways. The present state of affairs is the joint result of authors, editors, peer reviewers, and publishers who continue to allow (and in some cases, (...) support) the publication of new works across a variety of genres that contain positive citations to the 40 plagiarizing articles and book chapters. The problem shows no signs of abating; the plagiarizing articles and book chapters continue to acquire positive citations in new publications, including authoritative reference works. The breach of research standards is further shown by the fact that even a non-existent publication by the plagiarist continues to acquire positive citations. (shrink)

In this paper we focus on what is referred to as the ‘mineness’ of experience, that is, the intimate familiarity we have with our own thoughts, perceptions, and emotions. Most accounts characterize mineness in terms of an experiential dimension, the first-person givenness of experience, that is subsumed under the notion of minimal self-consciousness or a ‘minimal self’. We argue that this account faces problems and develop an alternative account of mineness in terms of the coherence of experiences with what we (...) label an ‘embodied biography’. Building on a near consensus among consciousness researchers over the function of consciousness as integrating infor- mation, we argue that the phenomenology of mineness consists in the absence of any further thought on top of the experience itself. Finally we argue that this non-phenomenological account of mineness fits well with existing data on pathologies of mineness such as delusions of thought insertion. (shrink)

Open peer commentary on the article “A Computational Constructivist Model as an Anticipatory Learning Mechanism for Coupled Agent–Environment Systems” by Filipo Studzinski Perotto. Upshot: The schema system presented in the target article suffers from problems that had been acknowledged more than ten years ago. The main point is that our world is neither deterministic nor symbolic. Sensory as well as motor noise is ubiquitous in our environment. Symbols do not exist a priori but need to be grounded within our continuous (...) world. In conclusion, I suggest that research on schema-learning systems should tackle small but real-world, continuous, and noisy problem domains. (shrink)

Open peer commentary on the target article “Who Conceives of Society?” by Ernst von Glasersfeld. First paragraph: Cognitive psychology, neurobiology, and cognitive systems research provide diverse clues as to how we are able to incrementally construct representations of the perceived environment and how we consequently understand other individuals and society. The construction of an individual’s reality starts with the capability to control one’s own body and to be able to predict the usual sensory effects caused by body movements. To be (...) able to infer the potential intentions of others, mirror neurons project one’s own behavioral codes onto perceived patterns that are caused by others. Equipped with representations of many other individuals, personal social realities are constructed. In this commentary, I focus on these points for the construction of social reality and the consequent existence of society as a whole. (shrink)

Open peer commentary on the article “Exploration of the Functional Properties of Interaction: Computer Models and Pointers for Theory” by Etienne B. Roesch, Matthew Spencer, Slawomir J. Nasuto, Thomas Tanay & J. Mark Bishop. Upshot: Although the authors investigate a form of distributed swarm intelligence and solve some problems with it – including sorting and summing – the major goal, which is constructing cognition, cannot be achieved by this approach alone. I propose that anticipatory mechanisms have the potential to construct (...) cognition and may very well be combined with swarm intelligence principles. (shrink)

Despite an increased recognition that plagiarism in published research can take many forms, current typologies of plagiarism are far from complete. One under-recognized variety of plagiarism—designated here as compression plagiarism—consists of the distillation of a lengthy scholarly text into a short one, followed by the publication of the short one under a new name with inadequate credit to the original author. In typical cases, compression plagiarism is invisible to unsuspecting readers and immune to anti-plagiarism software. The persistence of uncorrected instances (...) of plagiarism in all its forms—including compression plagiarism—in the body of published research literature has deleterious consequences for the reliability of scholarly communication. Not the least of these problems is that original authors are denied credit for their discoveries. When unsuspecting researchers read articles that are the products of plagiarism, they unwittingly engage the arguments of hidden original authors through the proxy of plagiarists. Furthermore, when these researchers later publish responses to the plagiarizing articles, not knowing they are engaging products of plagiarism, they create additional inefficiencies and redundancies in the body of published research. This article analyzes a suspected instance of compression plagiarism that appeared within the pages of this journal and considers the particular ways in which plagiarism of this variety weakens the quality of scholarly argumentation, with special attention paid to the field of philosophy. (shrink)

Individuals discovered to have engaged in serial plagiarism in philosophy are few, but the academic publishers falling victim to them are many. Some of the most respected publishing houses in philosophy have recently dealt with the problem of having published plagiarized material. The various responses by these publishers to an instance of serial plagiarism, one that involves forty-three articles and book chapters, provides a real-time snapshot of the practices for correcting the scholarly record. The analysis offered in this article yields (...) a twofold conclusion: first, there is relatively little uniformity among publishers in philosophy for responding to plagiarism; and second, in comparison with the natural sciences the discipline of philosophy often falls short of the accepted practices for correcting the scholarly record. The article considers only public, documented cases of academic plagiarism in philosophy and makes no new allegations of plagiarism. (shrink)

The study of the “first wave” of reactions to the Critique of Pure Reason in Germany from the second half of the 1780s until the beginning of the nineteenth century reveals the paradoxical status of the Kantian transcendental subject. While the existence of the transcendental subject, whatever the term means, is not open to question since it arises from the very essence of critical philosophy, the fundamental status of the subject is sometimes questioned in this period. Although the meaning of (...) the concept of transcendental subject seems obvious today it lends itself to various interpretations in the late eighteenth century. To achieve my goal I have undertaken a textological analysis of the works of the earliest opponents and followers of the Kantian critique and a reconstruction of the conceptual field in the midst of which the transcendental subject has been planted. Among others I draw on the works of J. S. Beck, J. A. Eberhard, J. G. Hamann, F. H. Jacobi, S. Maimon, K. L. Reinhold, G. E. Schulze and A. Weishaupt. The authors of the period are grouped depending on the common themes and questions that prompted them to turn to the concept of the transcendental subject, even though the results of their reflections did not always coincide. These authors think of the transcendental subject in its relationship to the transcendental object, or as “something = х”, and in terms of the relationship of representation to the object. It is characterised sometimes as something absolutely hollow, and sometimes as the fullness of true reality. The status ascribed to the transcendental subject is sometimes that of a thing-in-itself and sometimes that of a “mere” idea. Finally, Kant’s transcendental subject was sometimes seen as something to be overcome and sometimes as an infinite challenge to understanding. (shrink)